Some of the most popular city to city routes for travelers in Italy are between major destinations like Rome, Florence, Venice, and Milan. The Rome to Florence route passes through the scenic Tuscan countryside, with the option to stop in hill towns like Siena or Orvieto along the way. From Florence, many visitors continue on to Venice, marveling at the unique canals and architecture of this city built on the water.

The route from Venice to Milan cuts through the northern Italian plains, with stops possible in cities like Verona or Padua. No matter the route, traveling between Italy’s iconic cities offers a chance to soak in the country’s history, culture, cuisine, and breathtaking vistas.